“Bioelectromagnetic research reveals clear evidence of joint actions at cell membranes of chemical cancer promoters and environmental electromagnetic fields. The union of these two disciplines has resulted in the first major new approach to tumor formation in 75 years, directing attention to dysfunctions in inward and outward streams of signals at cell membranes, rather than to damage DNA in cell nuclei, and to synergic actions of chemical pollutants and environmental electromagnetic fields.” Dr. William Ross Adey (1990)
Wireless Radiation and Promotion of Cancer Growth
Researchers looking at sperm cells, nerve cells and in vivo rodent studies have found that low power radio frequency (microwave) electromagnetic radiation (RF EMR) from wireless devices can alter DNA, promote cancer growth and act as a co-carcinogen. Dr. W Ross Adey (1988 and 1990) and others in the 1980’s were well aware of the non-thermal, non-linear, molecular nature of toxicity for both non-ionizing electromagnetic radiation but also for chemical interactions that cause cellular membrane alterations, leading to cancer and other chronic diseases. Dr. Adey coined the term “biological windows” to highlight specific modulation, frequency and amplitude resonance effects on biological systems. Markov (2005) Research since then has confirmed and enriched our knowledge of the mechanisms and pathways of biological harm, including complex membrane calcium channel effects. Both chemicals, which are ingested, inhaled or absorbed through the skin and non-ionizing radio frequency radiation, which passes through organisms, can broadly affect many organ systems through electrical and molecular pathways. These can thus act separately or synergistically as environmental toxins, broadly affecting human and environmental health.
Lurchi in 2015 found an increase in liver tumors, lung tumors and lymphomas in mice at low to moderate exposure at (0.04 and 0.4 W/kg SAR), and well below exposure limits for the users of mobile phones. The recent NTP study, the new Falcioni study of 2018 and an older study by Chou in 1992 found scientific evidence of carcinogenicity, demonstrating the reproducibility of this effect. There are variable results for some studies, that are felt to be due to stimulation of feedback and repair mechanisms with exposure to radio frequency radiation. Initially, exposure to RFR stimulates DNA repair mechanisms, however, over longer periods of stimulation biochemical systems are overwhelmed, the DNA damage accumulates and the carcinogenic effect becomes evident.
Non- Thermal Mechanisms Found
The mechanisms more recently revealed, of how even weak radio frequency radiation can cause harm from long term exposure, are complex and do not involve heat damage. The injury is caused by membrane disruption interactions through calcium channels, reactive oxygen species, melatonin reduction or other direct or indirect mechanisms which promote cellular proliferation, angiogenesis and cancer. As noted above, chemical and heavy metal exposures work in similar non-thermal pathways.
Robust Non-Thermal Radio-frequency Scientific Literature Not Considered in Policy
A 2018 research compendium, 5G- Great Risk for EU, US and International Health by Dr. Martin Pall, highlights the threats of current 2G, 3G and 4G technology as well as proposed massive 5G technology rollout. Dr. Pall underscores how the European Commission’s Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR), states that the evidence is inconsistent with regards to harm from wireless technology. In a careful and well referenced review of the SCENIHR scientific policy documents, however, Dr Pall reveals that significant number of robust peer reviewed scientific articles were not considered in their deliberations.
More long term studies are needed to uncover adverse latent effects prior to any 5G deployment. Regarding current wireless communication safety, government agencies need to examine all the current scientific literature before proclaiming that no conclusions can be drawn. Disregarding science does not serve the public interest, especially as industry is developing and promoting a much more extensive worldwide wireless telecommunications system broadening the use of all frequency bands.
National Toxicology Program Study Reveals “Clear Evidence” of Carcinogenicity
The recently released 10 year $25 million United States National Toxicology Program (NTP) study which examined cell phone radiation and cancer, confirmed other epidemiological studies showing an elevation of schwannomas of the heart and gliomas in the brain of mice exposed to radio frequency radiation at non-thermal levels. NTP Study Full Report Feb 2, 2018. This was in addition to an increase in lymphoma and cancer of other organs with whole body exposure to this non-ionizing radiation which passes through the body. Based on this researchers are asking for radio frequency radiation to be upgraded to a classification as a probable (Group 2A) or known (Group 1) carcinogen, See also Scientific Literature on NTP Study on Cancer 2018.
This new research is supported by a similar long term study of effects of cell phone radiation and carcinogenicity in animals from the famed Ramazanni Institute in Italy as well as basic science research and older studies looking at occupational and military exposures.
International Agency for Research on Cancer (IARC)
The International Agency for Research on Cancer (IARC) listed radio frequency radiation from cell phones and wireless devices as a Class 2B Possible Carcinogen in 2011. Many researchers currently believe that this type of non-ionizing radiation that we are increasing and unknowingly exposed to should be classified as a Class 2A or probable carcinogen or even a class 1 or known carcinogen.
Some physicians believe this should be classified as a Group 1 (Known Carcinogen) or Group 2A (Probable Carcinogen)..
Dr. Annie Sasco, International Agency for Research on Cancer
Dr. Annie Sasco, former IARC Unit Chief and Emeritus Director of Research and Epidemiology on Cancer Prevention, discusses her reasoning for elevating the IARC classification at a symposium in 2017 sponsored by Environmental Health Trust. Dr. Annie Sasco explains why non-ionizing wireless radiation should be upgraded to a Group 2A carcinogen.
Dr. Ann Sasco presents her findings on childhood cancer prevention at the Childhood Cancer Conference in the UK 2012. Session 12 : What Positive Steps Can be Taken to Reduce the Risk of Childhood Cancer? Alliance for Prevention and Precaution for Childhood Cancer Control
Dr. Anthony Miller, Former WHO Advisor
Dr. Anthony Miller, Professor Emeritus at the University of Toronto Dali Lama School of Public Health, adviser to the World Health Organization and expert on ionizing and non-ionizing radiation feels the listing to be upgraded to a Class 1 Known Carcinogen. Dr. Anthony Miller on IARC Classification of RF EMR
Bioinitiative Report Update Supports IARC Classification of RF as Group 1 Known Carcinogen
Dr. Lennart Hardell and Michael Carlberg have reanalyzed the epidemiological studies on brain tumors and RF EMR from cell phone radiation and they also feel it should be a Group 1 Known Carcinogen. His analysis is found in Section 11 of the BioInitiative Report .
Published Literature on Cancer and Radiofrequency Radiation
Below is published scientific literature on cancer and wireless radio frequency electromagnetic radiation (RF EMR) from cell towers and other wireless devices, as well as co-carcinogenic effects. Other brain cancer studies, DNA and RNA damage from RF EMR exposure and reproductive studies can be found on our website at:
- Brain Cancer Studies: Cell Phones and Brain Cancer.
- DNA and RNA Research: DNA and RNA effects of RF EMR
- DNA Human Effects: DNA Human Studies
- Sperm and Ovarian Studies: Reproductive Health Effects
- Mechanisms of Action Research: Cellular Mechanisms EMR: Calcium Channels and Cellular Mechanisms Oxidation
- NTP Study on Cell Phones and Cancer 2018 NTP Study Cell Phones and Cancer-PST
Reviews on Cancer and RF EMR
1) Non-ionizing radiation, part 2: radio frequency electromagnetic fields. WHO IARC. Volume 102. 2011. https://monographs.iarc.fr/ENG/Monographs/vol102/mono102.pdf
Published Articles on Cancer and RF EMR ( by date)
- Effect of cell-phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells. (2018) Alahmad YM. Head Neck. 2018 May 13. https://www.ncbi.nlm.nih.gov/pubmed/29756334
- TOXICOLOGY AND CARCINOGENESIS STUDIES IN Hsd:SPRAGUE DAWLEY SD RATS EXPOSED TO WHOLE-BODY RADIO FREQUENCY RADIATION AT A FREQUENCY (900 MHz) AND MODULATIONS (GSM AND CDMA) USED BY CELL PHONES. (2018). National Toxicology Program, National Institute of Health (NIH). March 26-28, 2018. NTP Technical Report- TOXICOLOGY AND CARCINOGENESIS STUDIES OF GSM- AND CDMA-MODULATED CELL PHONE RADIO FREQUENCY RADIATION AT 900 MHz IN Hsd:SPRAGUE DAWLEY SD RATS 2018
- Report of final results regarding brain and heart tumors in Sprague-Dawley rats exposed from prenatal life until natural death to mobile phone radiofrequency field representative of a 1.8 GHz GSM base station environmental emission. (2018) Falcioni L, et al.Environmental Research. March 7, 2018/ https://www.sciencedirect.com/science/article/pii/S0013935118300367?via%3Dihub
- Report of Partial findings from the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley® SD rats (Whole Body Exposure). (2016) BioRxiv. Cold Spring Harbor Laboratory. http://biorxiv.org/content/early/2016/05/26/055699
- Some Effects of Weak Magnetic Fields on Biological Systems: RF fields can change radical concentrations and cancer cell growth rates. (2016) IEEE Power Electronics Magazine. Volume 3. Issue 1. 2016. http://ieeexplore.ieee.org/document/7425396/?arnumber=7425396
- Tumor promotion by exposure to radiofrequency electromagnetic fields below exposure limits for humans. (2015) Lerchi et al. Biochem Biophys Res Commun.2015 Apr 17;459(4):585-90. https://www.ncbi.nlm.nih.gov/pubmed/25749340 http://www.sciencedirect.com/science/article/pii/S0006291X15003988
- Positive correlation between ELF and RF electromagnetic fields on cancer risk. (2015) Mahdavi M et al. J Paramed Sci 6(3), ISSN 2008-4978. https://www.researchgate.net/publication/281579026_Positive_correlation_between_ELF_and_RFelectromagnetic_fieldon_cancer_risk
- Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A). (2015) Morgan et al. Int J Oncol 46(5): 1865-1871. https://www.researchgate.net/publication/273150433_Mobile_phone_radiation_causes_brain_tumors_and_should_be_classified_as_a_probable_human_carcinogen_2A_Review
- Scientific evidence contradicts findings and assumptions of Canadian Safety Panel 6: microwaves act through voltage-gated calcium channel activation to induce biological impacts at non-thermal levels, supporting a paradigm shift for microwave/lower frequency electromagnetic field action. (2015) Pall M. Rev Environ Health. 2015;30(2):99-116. https://www.ncbi.nlm.nih.gov/pubmed/25879308
- Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. (2015) Zhou,Y et al. Science August 21, 2015. 2015 Aug 21;349(6250):873-6. http://www.ncbi.nlm.nih.gov/pubmed/?term=Membrane+potential+modulates+plasma+membrane+phospholipid+dynamics+and+K-Ras+signaling
- Spin Biochemistry Modulates Reactive Oxygen Species (ROS) Production by Radio Frequency Magnetic Fields. (2014) Usselman RJ et al. Plos One. March 28, 2014. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093065
- Human disease resulting from exposure to electromagnetic fields. (2013) Carpenter DO. Rev Environ Health 2013;28:159-172.gj https://www.ncbi.nlm.nih.gov/pubmed/24280284
- Swedish review strengthens grounds for concluding that radiation from cellular and cordless phones is a probable human carcinogen. (2013) Davis DL et al. Pathophysiology 20:123-129. https://www.researchgate.net/publication/236690284_Swedish_review_strengthens_grounds_for_concluding_that_radiation_from_cellular_and_cordless_phones_is_a_probable_human_carcinogen
- Use of mobile phones and cordless phones is associated with increased risk for glioma and acoustic neuroma. (2013) Hardell L et al. Pathophysiology 2013;20(2):85-110. https://www.researchgate.net/publication/233974476_Use_of_mobile_phones_and_cordless_phones_is_associated_with_increased_risk_for_glioma_and_acoustic_neuroma
- Cancer induction molecular pathways and HF-EMF irradiation. (2013) Ledoigt G and Belpomme D. Adv Biol Chem 3:177-186. http://www.ehs-mcs.org/fichiers/1368798016_publication_ABC.pdf
- Multifocal Breast Cancer in Young Women with Prolonged Contact between Their Breasts and Their Cellular Phones. (2013) West JG1, Kapoor NS, Liao SY, Chen JW, Bailey L, Nagourney RA. Case Rep Med. 2013;2013:354682 http://www.ncbi.nlm.nih.gov/pubmed/24151509
- Biointiative Working Group. (2012) David Carpenter and Cindy Sage (eds). 2012 Bioinitiative 2012: A rationale for biologically-based exposure standards for electromagnetic radiation. http://www.bioinitiative.org
- Cellular neoplastic transformation induced by 916 MHz microwave radiation.(2012) Yang L Cell Mol Neurobiol. 2012 Aug;32(6):1039-46. https://www.ncbi.nlm.nih.gov/pubmed/22395787
- Carcinogenicity of radiofrequency electromagnetic fields. (2011) Baan R et al. Lancet Oncol. 2011;12(7):624-6. http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(11)70147-4/fulltext
- Non-ionizing radiation, part 2: radio frequency electromagnetic fields. (2011) WHO IARC. Volume 102. 2011. https://monographs.iarc.fr/ENG/Monographs/vol102/mono102.pdf
- Long Term Exposure to Microwave Radiation Provokes Cancer Growth: Evidences from Radars and Mobile Communication Systems. (2011) Yakymenko I . Experimental Oncology. March 2011. http://exp-oncology.com.ua/article/1845/long-term-exposure-to-microwave-radiation-provokes-cancer-growth-evidences-from-radars-and-mobile-communication-systems
- International Agency for Research on Cancer (IARC). IARC Classifies Radiofrequency Electromagnetic Fields as Possibly Carcinogenic to Humans. (2011) May 2011. See Reviews on Cancer above for studies. http://www.iarc.fr/en/media-centre/pr/2011/pdfs/pr208_E.pdf
- Electromagnetic fields and cancer: the cost of doing nothing. (2010) Carpenter DO Rev Environ Health 25:75-80. https://www.ncbi.nlm.nih.gov/pubmed/20429163
- NON-THERMAL EFFECTS AND MECHANISMS OF INTERACTION BETWEEN ELECTROMAGNETIC FIELDS AND LIVING MATTER. (2010) RAMAZZINI INSTITUTE. Giuliani L and Soffriti M (Eds). J. ONCOL. LIBRARY Volume 5, National Institute for the Study and Control of Cancer and Environmental Diseases “Bernardino Ramazzini” Bologna, Italy 2010, 400 page monograph. https://www.ramazzini.org/wp-content/uploads/2008/03/Non-thermal-effects-and-mechanisms-of-interaction-between-electromagnetic-fields-and-living-matter_2010.pdf
- Epidemiological evidence for a health risk from mobile phone base stations. (2010) Khurana VG et al. J. Occup. Environ. Health 16, 263-267. https://www.ncbi.nlm.nih.gov/pubmed/20662418
- Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model. (2010) Tillmann T. Int J Radiat Biol. 2010 Jul;86(7):529-41. https://www.ncbi.nlm.nih.gov/pubmed/20545575
- Risks of carcinogenesis from electromagnetic radiation and mobile telephony devices. (2010) Yakymenko I and Sidorik E. Exp Oncol 32:729-736. https://www.ncbi.nlm.nih.gov/pubmed/20693976
- Microwaves from UMTS/GSM mobile phones induce long-lasting inhibition of 53BP1/gamma-H2AX DNA repair foci in human lymphocytes. (2009) Belyaev IY et al. 2009 Feb;30(2):129-41. https://www.ncbi.nlm.nih.gov/pubmed/18839414
- Long-term exposure to magnetic fields and the risks of Alzheimer’s disease and breast cancer: Further biological research. (2009) Davanipour Z and Sobel E. Pathophysiology. 2009, Vol 16:149-156. https://www.ncbi.nlm.nih.gov/pubmed/19278839
- Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on the male reproductive system. (2009) Desai NR, Kesari KK, Agarwal A. Reproduct Biol Endocrinol. 7:114. doi: 10.1186/1477-7827-7-114. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776019/
- Cell phones and brain tumors: a review including the long-term epidemiologic data. (2009) Khurana VG et al. Surg Neurol 72:205-214. https://www.ncbi.nlm.nih.gov/pubmed/19328536
- Meta-analysis of long-term mobile phone use and the association with brain tumors. (2008) Hardell et al. Int J Oncol 32:1097-1103. https://www.ncbi.nlm.nih.gov/pubmed/18425337
- A new electromagnetic exposure metric: high frequency voltage transients associated with increased cancer incidence in teachers in a California school. (2008) Milham S1, Morgan LL.. Am J Ind Med. 2008 Aug;51(8):579-86. https://www.ncbi.nlm.nih.gov/pubmed/18512243
- Biomarkers of induced electromagnetic field and cancer. (2007) Behari J and Paulraj R. Indian J Exp Biol 45:77-85. https://www.ncbi.nlm.nih.gov/pubmed/17249331
- Cell type specific redox status is responsible for diverse electromagnetic field effects. (2007) Simkó M. Curr Med Chem. 2007;14:1141–52. https://www.ncbi.nlm.nih.gov/pubmed/17456027
- “Biological Windows”: A Tribute to W. Ross Adey. (2005) Marko Markov. The Environmentalist. 25:67-74, 2005. https://link.springer.com/article/10.1007/s10669-005-4268-8
- Use of cellular or cordless telephones and the risk for non-Hodgkin’s lymphoma.(2005) Hardell L. Int Arch Occup Environ Health. 2005 Sep;78(8):625-32. http://www.ncbi.nlm.nih.gov/pubmed/16001209
- The Influence of Being Physically Near to a Cell Phone Transmission Mast on the Incidence of Cancer. (2004) Egger H et al. January 2004. https://www.researchgate.net/publication/241473738_The_Influence_of_Being_Physically_Near_to_a_Cell_Phone_Transmission_Mast_on_the_Incidence_of_Cancer
- Mobile telephones and cancer – a review of the epidemiological evidence. (2004) Kundi M et al. J Toxicol Env Health, Part B 7:351-384. https://www.ncbi.nlm.nih.gov/pubmed/15371240
- Increased Incidence of Cancer Near a Cell Phone Transmitter Station. (2004) Wolf and Wolf. Kaplan Medical Center, Israel. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.527.1036&rep=rep1&type=pdf
- Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects. (2002) Leszczynski D. Differentiation. 2002 May;70(2-3):120-9. https://www.ncbi.nlm.nih.gov/pubmed/?term=12076339
- Cancer in radar technicians exposed to radiofrequency/microwave radiation: sentinel episodes. (2000) Richter E. Int J Occup Environ Health. 2000 Jul-Sep;6(3):187-93. https://www.ncbi.nlm.nih.gov/pubmed/10926722
- Epidemiologic evidence relevant to radar (microwave) effects. (1997) Goldsmith JR. Env Health Perspect 105(Suppl 6):1579-1587. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469943/
- Epidemiological studies of radio-frequency radiation: current status and areas of concern. (1996) Goldsmith JR. Science of the Total Environment. Volume 180, Issue 1,2. February 1996 , Pages 3-8. https://www.sciencedirect.com/science/article/pii/0048969795049142
- Cancer morbidity in subjects occupationally exposed to high frequency (radiofrequency and microwave) electromagnetic radiation. (1996) Stanislaw Szmigielski. Science of the Total Environment. Volume 180, Issue 1,2. 2 February 1996 , Pages 9-17. https://www.sciencedirect.com/science/article/pii/0048969795049150
- Electromagnetic field interactions with biological systems. (1993) Frey AH F FASEB J. 1993 Feb 1;7(2):272-81. https://www.ncbi.nlm.nih.gov/pubmed/8440406
- Long-Term Low-Level Microwave Radiation of Rats. (1992) Bioelectromagnetics. 13:469-496. 1992. C.-K. Chou et al. https://www.ncbi.nlm.nih.gov/pubmed/1482413 https://ecfsapi.fcc.gov/file/60002060833.pdf
- Joint actions of environmental nonionizing electromagnetic fields and chemical pollution in cancer promotion. (1990) Adley WR. Environ Health Perspect 86:297-305. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567752/
- Cell membranes: The electromagnetic environment and cancer promotion. (1988) Adey WR. Neurochem Res. July 1988, Vol 13:671-677. https://link.springer.com/article/10.1007/BF00973286
- A Current Literature Report on the Carcinogenic Properties of Ionizing and Nonionizing Radiation. (1978) Dwyer M J and Leeper D B, Department of Health Education and Welfare (DHEW) Publication (NIOSH) 78-134, March 1978. https://www.cdc.gov/niosh/nioshtic-2/00080942.html
- Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development. Sage C. Child Dev. 2017 May 15https://www.ncbi.nlm.nih.gov/pubmed/28504324
- Tumor promotion by exposure to radiofrequency electromagnetic fields below exposure limits for humans. Lerchl A. Biochem Biophys Res Commun. 2015 Apr 17;459(4):585-90. https://www.ncbi.nlm.nih.gov/pubmed/25749340
- Cellular neoplastic transformation induced by 916 MHz microwave radiation. Yang L1. Cell Mol Neurobiol. 2012 Aug;32(6):1039-46. https://www.ncbi.nlm.nih.gov/pubmed/22395787
- Combined Toxic Exposures and Human Health: Biomarkers of Exposure and Effect.(2011) Sillons,I. Int J Environ Res Public Health. 2011 Mar; 8(3): 629–647 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083662/
- Indication of co-carcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model. Tillmann T. Int J Radiat Biol. 2010 Jul;86(7):529-41. https://www.ncbi.nlm.nih.gov/pubmed/20545575
Related Articles Oxidation/Antioxidants and Cocarcinogenicity
- Combined Toxic Exposures and Human Health: Biomarkers of Exposure and Effect. (2011) Sillons I, Int J Environ Res Public Health. 2011 Mar; 8(3): 629–647. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083662/
- Free Radicals, Antioxidants in Disease and Health. (2008) Lien Ai Pham-Huy et al.. Int J Biomed Sci. 2008 Jun; 4(2): 89–96. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/