Updated 6/9/20
Note: Scientific Articles follow the summary
Scientific Literature
Blue Light, Retinal Damage, Computer Vision Syndrome, Skin Damage, Melatonin Reduction from Screens, Circadian Rhythm disruption, Myopia, and Wireless Radiation Oxidation
Digital Screen Time: Dry Eye, Cataracts, Computer Vision Syndrome
It is well established that eye structures are harmed by exposure to solar UV radiation. Points De Vue 2017. That is why ophthalmologists and optometrists advise wearing UV protective sunglasses when outdoors. Newer research is now demonstrating a host of serious risks associated with exposure to digital screens, blue light and radiofrequency radiation from wireless devices. The American Academy of Ophthalmology is concerned that too much screen time is now affecting children’s vision, including myopia and dry eye symptoms. Retinal phototoxicity from blue light is now established as a risk. Sleep and human circadian sleep disruption by blue light is considered essentially proven by health authorities. Increased screen time is now identified as a risk factor for dry eye syndrome and computer vision syndrome. Research has also revealed damage to skin from radiation from digital screens as well.
Researchers are concerned as our exposure to artificial blue-rich lighting is almost constant. The number of commercial products using blue lights has mushroomed and includes not only screens we stare at all day and night but also commercial products such as decorative string lights and toys which have bare LEDs. Even short exposures can have disruptive effects,
Skin is Vulnerable
The skin is the largest organ of the body and vulnerable to injury from many environmental factors. We are well informed about the dangers of UV exposures from the sun and suntanning booths, which can cause skin cancers, loss of skin elasticity and aging. Arjmandi (2018) spotlights the lesser known hazard of blue light, emitted from light emitting diodes (LED) screens, on skin. He describes the known mechanism of oxidative damage to the skin from exposure to both UV radiation, and the more recent addition of LEDs to our environment.
LED lights are widely used on cell phones, laptops, tablets, televisions and overhead lighting, in the effort to save energy. We now get almost constant exposure to blue light while we are awake day and night and both indoors on screens and outdoors on streetlights. In reviewing the literature on blue light harm in his article, “Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?“, research shows the answer is yes, and with just one hour of screen time at 1cm. We hold the phone closer than that on a call. He underscores that the effects of long term and intermittent exposures to skin are not known.
Screen Use and Acne
Published papers report that in vitro (lab experiments) blue light kills skin bacteria. While researchers are hopeful it will be used as phototherapy for acne, Taheri (2017) used the actual cell phone screens to see what they would do to staphylococcus aureus, a common acne bacteria. His group found, for the first time, that exposure to tablet and smartphone screen radiation significantly increased the rate of growth of staphylococcus bacteria and the maximum growth was at 300 minutes of exposure. It is possible that there is a combination of factors involved, as Sid- Salman (2019) found that a Wi Fi router increased antibiotic resistance and motility of E Coli and increased metabolic activity and biofilm production in Staphylococcus Aureus and Staphylococcus Epidermis.
Eyes Are Vulnerable
The eyes are uniquely vulnerable as they have no outer protective layer. Studies demonstrate cumulative damage to the cornea and lens of the eye with long-term UV/sunlight exposure (noted above) and now evidence is also pointing to blue light and non-ionizing radiation from wireless devices as causal agent for cataracts with a similar mechanism of oxidative damage.
Blue Light, Retinal Damage, Insomnia and Chronic Disease
Published data is documenting that LED blue light from screens and lighting is a true risk for oxidative retinal damage and circadian rhythm disruption, as well as melatonin reduction causing sleep disruption. Sleep disruption (or chronic insomnia) can have a profound effect on our health, and is associated with a host of chronic diseases, including cancer, obesity, high blood pressure, heart disease, poor memory, depression and anxiety, as well as poor learning performance. Melatonin, an important internal antioxidant, also protects eye structures from oxidative damage from a variety of sources.
French Health Authority Publishes Expert Appraisal of Blue Light
In 2014 ANES, the French Agency for Food, Environmental and Occupational Health & Safety, convened a Working Group to assess the effects on human health and the environment of systems using light-emitting diodes (LEDs). Their goal was to measure current real life levels of blue light exposure of children, the general public and workers to blue light and then to assess risks. This was in response to policies developed to remove halogen and incandescent lighting to reduce energy consumption.
They found that blue light has phototoxic, circadian rhythm and sleep effects. Blue light produces more glare and there is also more variation in light intensity depending on the power supply.
ICNIRP Guidelines for Blue Light Are Obsolete
ANES noted that the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines published in 2013 for blue light were the same as those published in 1997 and involved only acute exposure and did not take into consideration that children’s eye are more vulnerable with more blue light entering the eye. More over there are no regulations for circadian rhythm disruption, glare or light modulation.
ANES Published Results 2019: Findings
- The risk of circadian disruption associated with exposure to blue-rich LED lights in the evening or at night is high and likely to adversely affect sleep duration and quality and impact cognitive functions
- Circadian rhythm disruption is a higher risk in infants, children, adolescents and young adults (due to a clear lens); pregnant women (potential health effects on the unborn child); night workers; those with sleep disorders and possibly those with migraines
- Professionals with potentially high exposure to LED lighting (surgeons, dentists, lighting professionals, lighting distributors, performing artists, people working in sport facilities, people working in agri-food facilities using LEDs (greenhouses, aquaculture), etc.) are at higher risk
- The retinal phototoxicity of acute (for less than eight hours) exposure to blue-rich light is proven
- The contribution of chronic (for several years) retinal exposure to blue-rich light (including sunlight) to the occurrence of ARMD is proven
- Studies have shown that the exposure limits (ELs) selected by ICNIRP for the retinal toxicity of light are not sufficiently protective
- The effect of blue-rich light on myopia is possible (whether positive or negative)
- The effect of blue-rich light on the occurrence of Sjögren syndrome is possible
Cataracts on the Rise
There is a continued rise in the prevalence and incidence of cataract surgery which is attributed to better access and diagnosis, without consideration of ubiquitous environmental causes, such as increased screen time with blue light exposure. With children, whose systems are still developing and who are now exposed to screens at home and now mandated at school, there are even more serious concerns.
Computer Vision Syndrome and Dry Eye
Computer Vision Syndrome (CVS) is an increasingly recognized but an under-diagnosed syndrome resulting from prolonged screen time with video display terminals (computers, laptops, tablets, cell phones). Symptoms include include headache, eyestrain, tired eyes, irritation, redness, blurred vision, and double vision. Dry eye symptoms often accompany CVS with reduced blinking rate and increased corneal exposure. There is evidence that atrophy of the lubricating meibomian glands around the eyes are involved as well. Researchers warn that people spending more than 4 hours a day at the screen are at major risk to develop dry eye symptoms and computer vision syndrome. It is estimated that 50 to 90 % of students and those who use computers at work experience this. The American Academy of Ophthalmology has recommendations to reduce eye strain with the use of digital devices.
Eye Strain
Using cell phones and tablets at close distances to view movies or read for long periods causes eyestrain. A study by Long (2017), Viewing distance and eyestrain symptoms with prolonged viewing of smartphones of young adults using a cell phone for 60 minute to read showed a significant increase in eye strain, with students reporting tired eyes, uncomfortable eyes and blurred vision. Another study by Antona (2018), Symptoms associated with reading from a smartphone in conditions of light and dark showed significant eyestrain from using a smartphone for prolonged periods versus a hardcopy, especially if the smartphone was used in the dark.
The 20-20-20 Vision Rule
Staring at screens from computers, cell phones, gaming, tablets and television for long periods of time can cause eye fatigue and computer vision syndrome with blurred vision tearing, and headaches. To reduce eye strain it is recommended to use the 20-20-20 rule: Every 20 Minutes look at something 20 feet away for 20 seconds. It is also recommended to:
- Position your screen an arms length away from your eyes and at 20 degrees below eye level
- Alternate from looking at your screen to looking at paperwork and your surroundings
- Match the brightness of your screen with surroundings
- Remember to blink. When we are not on the computer we blink 12 times a minute but when on the computer we blink only 5 times a minute
- See a physician if you have symptoms of computer vision syndrome
- Consider a low blue light computer shield or low blue light glasses from a reputable company that reduce blue light.
China Bans Digital Screens in Classrooms to Prevent Eye Damage
Because of the growing evidence for the risk of eye damage from digital screens and research showing an association with myopia, China has banned cell phones from classrooms. See China Bans Smart Phones in Schools . The Ministry of Education and the National Health Commission has banned the use of cell phones and tablets in classrooms in Shandong province and asked parents and teachers to:
- Not rely on electronic devices for teaching and assignments and use written assignments
- Limit children’s use of electronic screens not more than one hour a day and not exceed 15 minutes in a single session
- Keep proper distance from eyes and screens
- Have correct reading positions
- Have sufficient backlighting
Retinal Oxidative Eye Damage and Blindness From Blue Light
Researchers from Sweden in 2006 reviewed the pathogenesis of age-related macular degeneration. In their paper looking at light damage, Age-related maculopathy and the impact of blue light hazard, they note that oxidative stress and free radical formation cause damage to cellular structures in the retina, leading to inflammation and lipofuscin deposition. They recommended antioxidants to slow age-related macular degeneration, which is more common after the age of 60.
University of Toledo scientists in the Department of Chemistry published a study in 2018 showing that exposure to Blue Light caused damage and death to photoreceptor cells in the retina. These photo receptor cells cannot regenerate, speeding up macular degeneration, which leads to blindness. Another 2018 study from Spain, Removal of the blue component of light significantly decreases retinal damage after high intensity exposure, demonstrated a 94% blue-blocking filter decreases significantly photoreceptor damage after exposure to high intensity light.
Osborne (2017) has researched the adverse effects of blue light on retinal mitochondria and found, “Neurones of the central nervous system have an absolute dependence on mitochondrial generated ATP. Laboratory studies show that short-wave or blue light (400–480 nm) that impinges on the retina affect flavin and cytochrome constituents associated with mitochondria to decrease the rate of ATP formation, stimulate ROS and results in cell death. This suggests that blue light could potentially have a negative influence on retinal ganglion cell (RGC) mitochondria”. Shang (2017), Aadane (2015), Shang (2014), Chamorro (2013) and Behar-Cohen (2011) are among others who have also demonstrated the serious oxidative effects of blue light from digital screens.
Research has shown that non-thermally related radio frequency radiation (RFR) can also cause ocular pathology and eye damage, with the creation of reactive oxygen species (ROS). This is an important consideration with exposure to wireless radio frequency radiation in 2G, 3G, 4G systems. It is an even higher concern for 5G proposed short millimeter wave technology, as this very short high frequency radiation has been shown to create more damage and higher heat concentration with use. Research on the adverse health effects on the eyes for 2G, 3G and 4G let alone 5G are severely lacking while wireless devices are increasingly being placed in close proximity to our brains and eyes. (Fernandez 2018, Sage 2018)
Blue Light from Digital Devices Blocks Melatonin, Sleep and Shifts the Circadian Clock
Researchers have now proven that use of digital devices at night such as cell phones, tablets, computers and TV’s with LED lighting and even overhead LED lighting, can interrupt sleep patterns as they emit blue light frequencies. Blue light hits receptors in retinal ganglion cells which sends a message to the suprachiasmatic nuclei of the hypothalamus, the seat of the central circadian clock. This retinal clock then sends the message to the rest of the body in order to synchronize all of the biological functions with the day/night cycle.(ANES) The secretion of the sleep signaling hormone melatonin by the pineal gland occurs only in darkness and is suppressed by blue light, thus altering the circadian rhythm.
West (2011) demonstrated that the strongest melatonin response was between 446 nm and 477 nm. In a recent study by UCSF, Direct Measurements of Smartphone Screen-Time: Relationships with Demographics and Sleep. scientists concluded,”Longer average screen-times during bedtime and the sleeping period were associated with poor sleep quality, decreased sleep efficiency, and longer sleep onset latency.” A other recent study by Chindamo (2019), Sleep and new media usage in toddlers, found everyday use of a tablet or smartphone raised the odds of a shorter total sleep time and a longer sleep onset latency. Excess screen time is also associated with other health issues as described in this paper by Kenny(2017), United States Adolescents’ Television, Computer, Videogame, Smartphone, and Tablet Use: Associations with Sugary Drinks, Sleep, Physical Activity, and Obesity.
Circadian Shifts With Blue Light
A Harvard study found that blue light suppressed melatonin for about twice as long as the green light and shifted circadian rhythms by twice as much as green light. The circadian shift was 3 hours for blue light and 1.5 hours for green light.
A study by Chang (2015), Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness, demonstrated that these LED devices can shift our natural sleep clock. The researches compared 2 groups of participants. One group read an e-book with LED (peak 450nm) lighting 4 hours before bed and the second group read a printed book again 4 hours before bed. In the e readers they found lower melatonin levels, less REM sleep and after 5 days they demonstrated a 1.5 hour phase shift in circadian clock., thus it took longer for them to fall asleep. Although at night the e readers were more alert, in the morning they were less alert. The researchers conclude, “Our findings provide evidence that the electric light to which we are exposed between dusk and bedtime has profound biological effects.”
Unborn Babies at Risk From Blue Light
Although blue light does not directly reach the fetus, scientists have found that the maternal reduction in melatonin, a potent internally produced antioxidant, may affect fetal neurodevelopment and be associated with autism spectrum disorder (ASD) (Jin 2018). Studies have shown that melatonin is a critical hormone that is neuropcrotecive in ASD and also protects from DNA damage.(Braam 2018)showed that melatonin “levels were significantly lower in mothers with an ASD child.”
Reiter (2013) notes that melatonin serves and important role in reproduction.”Melatonin is a multifaceted molecule with direct free radical scavenging and indirect antioxidant activities. Melatonin is produced in both the ovary and in the placenta where it protects against molecular mutilation and cellular dysfunction arising from oxidative/nitrosative stress….Optimal circadian rhythmicity in the mother is important since her circadian clock, either directly or indirectly via the melatonin rhythm, programs the developing master oscillator of the fetus.” Disrupted melatonin cycles are associated with disturbances in behavior in the newborn.
Hsu (2020) reviewed the literature and concludes that reduction in maternal melatonin could affect signaling pathways, predisposing the fetus to a number of adult chronic health conditions. They describe the critical role that melatonin plays in development. Melatonin receptors are present in many tissues in the human fetal brain. Although the fetal pineal gland does not secrete melatonin until after birth, maternal pineal melatonin does cross the placenta. Maternal light signals thus can be transferred to the fetus. The biological clock is run by a complex system of molecular signals affecting transcription and stress pathways. The authors note, “Placenta-derived melatonin acts as an autocrine, paracrine, and endocrine hormone in a non-circadian fashion…Placenta-derived melatonin not only acts with the MT1 and MT2 receptors but also directly scavenges free radicals, which reduce oxidative damage to placental tissues.”
French Agency for Food, Environmental and Occupational Health & Safety on LED Lights 2019
ANES, the French Agency for Food, Environmental and Occupational Health & Safety published an extensive independent report on the “effects on human health and the environment (fauna and flora) systems using light-emitting diodes (LEDs).
They noted, “Over the past few decades, humans have considerably increased their exposure to blue light in the evening with artificial lighting and backlights rich in blue light…the Working Group’s experts consider that the risk of circadian disruption associated with exposure to blue-rich LED lights in the evening or at night is high. In particular, exposure before bedtime to LED lighting or screens from televisions or communication technologies enriched with blue light is likely to adversely affect sleep duration and quality and impact cognitive functions.” Their 2019 report is here- 5G ANSES French Study Blue Light 2020.
Doctors Warn That LED City Street Lights Blue Spectrum Can Cause Sleep Disruption
In 2016 the American Medical Association warned cities that the new energy efficient street light that were being installed to combat global climate change can harm the retina, affect circadian rhythms and sleep patterns. Studies have shown that brighter residential nighttime lighting is associated with sleep disruption. AMA Board Member Maya A. Babu, M.D., M.B.A states, “Despite the energy efficiency benefits, some LED lights are harmful when used as street lighting, The new AMA guidance encourages proper attention to optimal design and engineering features when converting to LED lighting that minimize detrimental health and environmental effects.”
News on Harm From LED Street Lamps
- AMA Adopts Guidance to Reduce Harm from High Intensity Street Lights. June 2016. https://www.ama-assn.org/ama-adopts-guidance-reduce-harm-high-intensity-street-lights
- Doctors issue warning about LED streetlights. June 2016. https://www.cnn.com/2016/06/21/health/led-streetlights-ama/index.html
- Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats. Environmental Health Perspectives 2014. https://ehp.niehs.nih.gov/122-a81/
- Do ‘environmentally friendly’ LED lights cause BLINDNESS? 2013. http://www.dailymail.co.uk/health/article-2324325/Do-environmentally-friendly-LED-lights-cause-BLINDNESS.html
Blue Light Blues: Melatonin Suppression and Breast Cancer
Blue light emitted from LED screens from computers, cell phones and tablets can inhibit melatonin production and alter circadian rhythms. Melatonin is a potent antioxidant, produced in the pineal gland, and is also found in the retina where it modulates genes responsible for circadian rhythms via the ganglion cell layer (Blasiak 2016). Researchers have found photosensitive retinal ganglion cells (ipRGCs) in the mammalian brain which are not related to image formation but direct circadian rhythms, pupil constriction and alertness through 465nm blue light Vandewalle(2018).
This cascade of biological effects contributes to a host of chronic disease states, including high blood pressure, depression and cancer.
Dr. David Blask and colleagues have conducted a series of studies showing that light suppresses melatonin leading to stimulation of breast cancer growth. When they grafted human MCF-7 breast cancer cell xenograft on mice and exposed one to light- light and the other to light-dark environments they found the light- light group had increased cancer cell growth rates. (Blask 2002) The International Agencyfor Cancer Research (IARC) classified shift work that involves circadian disruption as a “probable carcinogen”. (IARC 2007)
See also MDSafeTech Scientific Literature on Sleep Melatonin and Light at Night.
Harvard Recommendations for Reducing Blue Light Exposure
LED lights from lightbulbs, computers, cell phones, video games and tablets emit blue light from the screen. Overhead LED lights that are now commonly used also emit more blue light than fluorescent light bulbs, and incandescent light bulbs emit the least blue light. Although much more energy efficient, LED lighting which has largely replaced incandescent in homes, businesses and street lights, may be creating a health risk through complex biologic effects on our melatonin levels and circadian rhythms. Here are the Harvard guidelines Blue light has a dark side. Updated August 13, 2018.
Protect yourself from blue light at night (Harvard 2018)
- Use dim red lights for night lights. Red light has the least power to shift circadian rhythm and suppress melatonin.
- Avoid looking at bright screens beginning two to three hours before bed.
- If you work a night shift or use a lot of electronic devices at night, consider wearing blue-light blocking glasses or installing an app that filters the blue/green wavelength at night.
- Expose yourself to lots of bright light during the day, which will boost your ability to sleep at night, as well as your mood and alertness during daylight.
https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side
Blue Light Blocking Glasses for Improved Physical and Mental Health
Amber colored blue light absorbing glasses, computer and cell phone screen covers have been developed to block blue light from artificial LED lighting and screens, typically 2-3 hours before bedtime. More research needs to be done, however, scientists have found that using these blue light blocking devices may promote higher melatonin levels near bedtime thus reducing insomnia. Evidence is showing the positive effects on blue light blocking glasses not only on sleep quality and timing (Zebrine 2018; Eskai 2016; Burkhart 2009) but also potentially on symptoms of mania in those with manic depressive symptoms by acting as physiologic “dark therapy” not necessarily related to melatonin production (Shirahama 2018; Henriksen 2016). Quality varies with the amount and spectrum of blue light blocked by different glasses. If you are purchasing glasses it is important to get high quality tested glasses and know which frequencies are blocked either full blue light blockage (400-500nm), full blue green blockage (400-550nm ) or specific blue frequencies (i.e.480nm) . In general the more full blue light spectrum blocked the better it will enhance melatonin production. Consumer Reports-3 Blue Blockers Put to the Test
Apple has introduced “Nightshift” software into their new phones (OS9.3 and above) that reduces blue light at night. You can access by pressing Settings >Display&Brightness >NightShift and set it to the times you wish the display to reduce blue light. Some research from the Lighting Research Center has shown that this Apple setting may not help you sleep as much as anticipated as the brightness of the screen and excess mental stimulation may also be factors on melatonin levels.
The Importance of Blocking Blue Light Peaks for Oxidation as well as for Normal Melatonin Production
Blue light spans 400 to 500nm. Retinal damage is caused by the span of blue light from 400-500nm, as well as lesser damage from green light 500-550 nm. Peak blue light at about 430nm is known to cause the most oxidative damage with regards to age related macular degeneration (ARM) in studies. Melatonin reduction has been found at a peak of about 450nm. It is important for full protection of the eyes to have full blue light blocking from 400-500nm. Many products sold have a very narrow range of blue light blocking. It is important to be aware of which parts of the blue light spectrum are absorbed by blue light blocking barriers before you purchase the glasses other blue light blocking products.
Dr. Vicente-Tejedor and colleagues demonstrated protection from blue light damage with broad blue light blocking.
Excitation and metabolic cycle of rhodopsin depending on the use of the blue-blocking filter. Wavelengths of the spectrum from 400-500nm excite rhodopsin and generate toxic waste but also cause retinal degeneration. From “Removal of the blue component of light significantly decreases retinal damage after high intensity exposure.” Vicente-Tejedor (2018)
Dr. Charles Czeisler Discusses Broad Health Impacts of Poor Sleep
Charles A. Czeisler, MD, PhD, Chief, Division of Sleep and Circadian Disorders at Brigham and Women’s Hospital, explains the critical impacts of sleep on brain function and physical health. He states that sleep is the third pillar of good health along with nutrition and exercise. Lowering blue light at night is component of healthy sleep. Dr. Czeisler , whose group has worked with astronauts to reset their circadian rhythms before going into space research, highlights the many bodily systems effected by insomnia including
- Brain Detoxification
- Cardiovascular
- Immune System
- Weight Gain
- Insulin Resistance / Pre diabetes
- Mood
Fatal Collision: Harm from Wireless Eyewear
A new 2018 paper, Fatal Collision: Are Wireless Headsets a Risk in Treating Patients?, highlights the potential bodily harm from wearing wireless headsets, augmented reality systems and glass-type eyewear. Co-authored by Cindy Sage, who is also co- author of the Bioinitiative Report, this review article reveals that these devices, are connected to the internet and have similar radiation (2.4 and 5GHz) to cell phones. An association has been identified between long term cell phone use and brain cancers on the same side of the head. There is also the concern for lack of concentration and distraction when using these devices, similar to cell phones. Damage to eye structures is an obvious concern.
These wireless devices are increasingly being used in medicine (google glass-type wearables) and by educators but no thought has been given to the harm from long term use. Children are seen in ads wearing wireless headsets for entertainment. It is the next best marketing and sales opportunity in technology. Sage and Hardell note, “using wireless glass-type devices can expose the user to a specific absorption rates (SAR) of 1.11–1.46 W/kg of radiofrequency radiation. That RF intensity is as high as or higher than RF emissions of some cell phones. Prolonged use of cell phones used ipsilaterally at the head has been associated with statistically significant increased risk of glioma and acoustic neuroma.” Studies are inadequate to determine safety of these wireless devices long term. There are to date insufficient protective guidelines for adults or children who are increasing using these devices for entertainment, in classrooms and therapeutically in medicine. Precautionary recommendations for use are needed.
Eye Absorption of Radiation from Cell Phones and Virtual Reality
A seminal paper Fernandez et al (2018) reveals that young eyes and brains absorb 2 to 5 fold more radiation than that of an adult. He cautions that we need to reexamine regulations and compliance with regards to these devices as testing uses a large adult male (SAM) . Dr. Fernandez also advises precautions proposed by the American Academy of Pediatrics, that young children should not use cell phones. This study indicated virtual reality type devices should also not be used by children. He urges wired connections to reduce children’s needless exposure to non-ionizing radiation. More research is critically needed in this area as widespread commercial use has already begun.
Reprinted with permission.
Headlines
- China bans mobile phones in classrooms: Primary and middle school students in Shandong province will not be allowed to use cellphones or tablets in classrooms starting from Nov 1, according to a new regulation.China Daily/Asia News Network. Oct 10, 2018. China Bans Smart Phones in Schools
- Light emitted from digital screens can cause irreversible damage to eyes, research shows. Jan 27, 2017.News Medical and Life Sciences. https://www.news-medical.net/news/20170127/Light-emitted-from-digital-screens-can-cause-irreversible-damage-to-eyes-research-shows.aspx
Published Studies Physiologic Eye Effects
Newest Articles
- Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease. (2020) Hsu CN et al. Int J Mol Sci. 2020 Mar 23;21(6):2232. https://pubmed.ncbi.nlm.nih.gov/32210175/
- Children’s Sleep May Depend on Maternal Sleep Duration During Pregnancy: A Retrospective Study. (2020) Lyu J et al. Nat Sci Sleep. 2020 Mar 10;12:197-207. https://pubmed.ncbi.nlm.nih.gov/32210651/
- Effects on human health and the environment (fauna and flora) of systems usinglight-emitting diodes (LEDs). (2019) French Agency for Food, Environmental and Occupational Health & Safety. https://www.anses.fr/en/system/files/AP2014SA0253EN.pdf
- Absorption of wireless radiation in the child versus adult brain and eye from cell phone conversation or virtual reality. (2018) Fernandez C et al. Environmental Research. June 5, 2018. https://www.sciencedirect.com/science/article/pii/S0013935118302561
- Impact of Light Exposure during Sleep on Cardiometabolic Function. (2018) Mason I et al. Sleep, Volume 41, April 2018, Pages A46. https://academic.oup.com/sleep/article-abstract/41/suppl_1/A46/4988151?redirectedFrom=fulltext
- Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones’ Screens Improves Human Sleep Quality. (2018) Mortazavi SAR. J Biomed Phys Eng. 2018 Dec 1;8(4):375-380. https://www.ncbi.nlm.nih.gov/pubmed/30568927
- Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin. (2018) Zerbini G Eur J Neurosci. 2018 Dec 2. https://www.ncbi.nlm.nih.gov/pubmed/30506899
Blue Light
Retinal Damage, Melatonin, Skin
- Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles? (2018) Arjmandi N et al. J Biomed Phys Eng. 2018 Dec 1;8(4):447-452. https://www.ncbi.nlm.nih.gov/pubmed/30568934
- The potential influence of LED lighting on mental illness. (2018) Bauer M et al. World J Biol Psychiatry. 2018 Feb;19(1):59-73. https://www.ncbi.nlm.nih.gov/pubmed/29251065
- The Relationship Between Autism Spectrum Disorder and Melatonin During Fetal Development. (2018) Y Jin et al. Molecules. 2018 Jan 18;23(1):198. https://pubmed.ncbi.nlm.nih.gov/29346266/
- Impact of Light Exposure during Sleep on Cardiometabolic Function. (2018) Mason I et al. Sleep, Volume 41, April 2018, Pages A46. https://academic.oup.com/sleep/article-abstract/41/suppl_1/A46/4988151?redirectedFrom=fulltext
- Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones’ Screens Improves Human Sleep Quality. (2018) Mortazavi SAR. J Biomed Phys Eng. 2018 Dec 1;8(4):375-380. https://www.ncbi.nlm.nih.gov/pubmed/30568927
- Women with hereditary breast cancer predispositions should avoid using their smartphones, tablets, and laptops at night. (2018) Mortazavi SAR and Mortazavi SMJ. Iran J Basic Med Sci. 2018 Feb;21(2):112-115. https://www.ncbi.nlm.nih.gov/pubmed/29456806
- Blue light excited retinal intercepts cellular signaling. (2018) Ratnayake K et al. Scientific Reports volume8, Article number: 10207 (2018). https://www.nature.com/articles/s41598-018-28254-8
- Use of Gray Sunglasses to Alleviate Hypomanic State in Two Patients with Bipolar II Disorder. (2018) Shirahama M et al.Bipolar Disord. 2018 Nov 14. https://www.ncbi.nlm.nih.gov/pubmed/30430720
- Light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-image-forming photoreception. (2018) Vandewalle G et al.Sci Rep. 2018 Nov 16;8(1):16968. https://www.ncbi.nlm.nih.gov/pubmed/30446699https://www.ncbi.nlm.nih.gov/pubmed/30446699
- Removal of the Blue Component of Light Significantly Decreases Retinal Damage After High Intensity Exposure. (2018) Vicente-Tejedor J et al. PLoS One. 2018 Mar 15;13(3):e0194218. https://pubmed.ncbi.nlm.nih.gov/29543853/
- Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin. (2018) Zerbini G Eur J Neurosci. 2018 Dec 2. https://www.ncbi.nlm.nih.gov/pubmed/30506899
- Blue Light Has a Dark Side (2018). Harvard Health publishing. Harvard Medical School. August 1, 2018. https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side
- Points De Vue. UV and Blue Light Ocular Risks. (2017) International Review of Ophthalmic Optics. Collection of Articles 2011-2017. http://www.pointsdevue.com/sites/default/files/UV-BlueLight-E-book-edition-2-web.pdf
- Effects of smartphone use with and without blue light at night in healthy adults: A randomized, double-blind, cross-over, placebo-controlled comparison. (2017) Jung-Yoon Heo et al. Journal of Psychiatric Research.Volume 87. April 2017 , Pages 61-70 http://www.sciencedirect.com/science/article/pii/S0022395616307786
- Visual light effects on mitochondria: The potential implications in relation to glaucoma. (2017) Osborn NN et al. Mitochondrion. Volume 36, September 2017 , Pages 29-35 https://www.sciencedirect.com/science/article/pii/S1567724916302586
- Light-emitting-diode induced retinal damage and its wavelength dependency in vivo.(2017) Shang YU et al. Int J Ophthalmol. 2017; 10(2): 191–202. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313540/
- Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration. (2016) Blasiak J et al. Oxid Med Cell Longev. 2016; 2016: 6819736. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027321/
- Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder: An open-label trial. (2016) Esaki Y et al. Chronobiol Int. 2016;33(8):1037-44. https://www.ncbi.nlm.nih.gov/pubmed/27322730
- Blue‐blocking glasses as additive treatment for mania: a randomized placebo‐controlled trial. (2016) Henriksen T et al. Bipolar Disord. 2016 May; 18(3): 221–232. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089565/
- The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. (2016) Nita M et al. Oxidative Medicine and Cellular Longevity. Jan 10, 2016. https://www.hindawi.com/journals/omcl/2016/3164734/
- Effects of blue light on the circadian system and eye physiology. (2016) Tosini G et al. Mol Vis. 2016; 22: 61–72. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734149/
- Retinal damage induced by commercial light emitting diodes (LEDs). (2015) Jaadane I et al. Free Radical Biology and Medicine. (84) 2015. Pg 373-384. https://www.researchgate.net/publication/274781116_Retinal_damage_induced_by_commercial_light_emitting_Diodes_LED
- Short-wavelength Enrichment of Polychromatic Light Enhances Human Melatonin Suppression Potency. (2015) Brainard GC et al. J Pineal REs. 2015 Apr;58(3):352-61. https://pubmed.ncbi.nlm.nih.gov/25726691/
- Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. (2015) Chang AM et al. PNAS.
- Light at night pollution of the internal clock, a public health issue. (2015) Touitou Y. Bull Acad Natl Med. 2015 Oct;199(7):1081-1098. https://www.ncbi.nlm.nih.gov/pubmed/29879330
- Timing of examinations affects school performance differently in early and late chronotypes. (2015) van der Vinne V et al. J Biol Rhythms. 2015 Feb;30(1):53-60. https://www.ncbi.nlm.nih.gov/pubmed/25537752
- Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention. (2014) Blask DE et al. PLoS One. 2014 Aug 6;9(8). https://www.ncbi.nlm.nih.gov/pubmed/25099274
- Blue Light–Induced Oxidative Stress in Human Corneal Epithelial Cells: Protective Effects of Ethanol Extracts of Various Medicinal Plant Mixtures. (2014) Lee JB et al. Investigative Ophthalmology and Visual Science. Vol 55. Issue 7. July 2014. https://iovs.arvojournals.org/article.aspx?articleid=2128327
- The effect of visual blue light on mitochondrial function associated with retinal ganglions cells. (2014) Osborne NN et al. Experimental Eye Research. Volume 128. November 2014 , Pages 8-14. https://www.ncbi.nlm.nih.gov/pubmed/25193034
- White Light-emitting diodes (LEDs) at domestic lighting levels and retinal injury in a rat model. (2014) Shang et al. Environmental Health Perspectives. Mar. 122(3): 269-76 https://www.ncbi.nlm.nih.gov/pubmed/24362357https://www.sciencedirect.com/science/article/pii/S001448351400236X
- Photoprotective Effects of Blue Light Absorbing Filter against LED Light Exposure on Human Retinal Pigment Epithelial Cells In Vitro. (2013) Chamorro et al., J Carcinog Mutagen 2013. https://www.researchgate.net/publication/269542796_Photoprotective_Effects_of_Blue_Light_Absorbing_Filter_against_LED_Light_Exposure_on_Human_Retinal_Pigment_Epithelial_Cells_In_Vitro
- Light-emitting diodes (LED) for domestic lighting: any risks for the eye? (2011) Behar-Cohen F. Prog Retin Eye Res. 2011 Jul;30(4):239-57. https://www.ncbi.nlm.nih.gov/pubmed/2160030
- Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans. (2011) West KE et al. J Appl Physiol (1985). 2011 Mar;110(3):619-26. https://www.ncbi.nlm.nih.gov/pubmed/21164152
- Nighttime use of special spectacles or light bulbs that block blue light may reduce the risk of cancer. (2009) Alpert M et al. Med Hypotheses. 2009 Sep;73(3):324-5. https://www.ncbi.nlm.nih.gov/pubmed/19375243
- Use of modified spectacles and light bulbs to block blue light at night may prevent postpartum depression. (2009) Bennett S et al. Med Hypotheses. 2009 Aug;73(2):251-3. https://www.ncbi.nlm.nih.gov/pubmed/19329259
- Amber lenses to block blue light and improve sleep: a randomized trial. (2009) Burkhart K1, Phelps JR. Chronobiol Int. 2009 Dec;26(8):1602-12. https://www.ncbi.nlm.nih.gov/pubmed/20030543
- Is light-at-night a health risk factor or a health risk predictor? (2009) Kantermann T, Roenneberg T.Chronobiol Int. 2009 Aug;26(6):1069-74. https://www.ncbi.nlm.nih.gov/pubmed/19731106
- IARC 2007. Press Release. IARC lists Shiftwork as Probable Carcinogen. https://www.iarc.fr/en/media-centre/pr/2007/pr180.html
- Age-related Maculopathy and the Impact of Blue Light Hazard. (2006) Algvere PV et al. Acta Ophthalmol Scand. 2006 FEb;84(1):4-15. https://pubmed.ncbi.nlm.nih.gov/16445433/
- Protective Effects of Soft Acrylic Yellow Filter Against Blue Light-Induced Retinal Damage in Rats. (2006) Tanito M et al. Exp eye REs. 2006 Dec;83(6):1493-504. https://pubmed.ncbi.nlm.nih.gov/16997296/
- Mobile phone related-hazards and subjective hearing and vision symptoms in the Saudi population. (2005) Meo SA and Al-Dress AM. Int J Occup Med Environ Health. 2005;18(1):53-7. https://www.ncbi.nlm.nih.gov/pubmed/16052891
- Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue. (2004) Pauley SM. Med Hypotheses. 2004;63(4):588-96. https://www.ncbi.nlm.nih.gov/pubmed/15325001
- Light during darkness, melatonin suppression and cancer progression. (2002) Blask DE. Neuro Endocrinol Lett. 2002 Jul;23 Suppl 2:52-6. https://www.ncbi.nlm.nih.gov/pubmed/12163849
- Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. (1999) Blask DE et al. Cancer Res. 1999 Sep 15;59(18):4693-701. https://www.ncbi.nlm.nih.gov/pubmed/10493527
Computer Vision Syndrome
- Prevalence of dry eye in video display terminal users: a cross-sectional Caucasian study in Italy. (2018). Rossi GCM et al. Int. Ophthalmol. https://www.ncbi.nlm.nih.gov/pubmed/29881936
- Eyesight quality and Computer Vision Syndrome.(2017) Bogdanici CM et al. Rom J Ophthalmic. 2017 Apr-Jun;61(2):112-116. https://www.ncbi.nlm.nih.gov/pubmed/29450383
- Visual Fatigue Induced by Viewing a Tablet Computer with a High-resolution Display. Kim DJ. Korean J Ophthalmic. 2017 Oct;31(5):388-393. https://www.ncbi.nlm.nih.gov/pubmed/28914003
- Computer vision syndrome prevalence, knowledge and associated factors among Saudi Arabia University Students: Is it a serious problem? (2017) Al Rashid SH. Int J Health Sci (Qassim) 2017 Nov-Dec;11(5):17-19. https://www.ncbi.nlm.nih.gov/pubmed/29114189
- Exploring the Predisposition of the Asian Eye to Development of Dry Eye. (2016) Craig JP et al. Ocul Surf. 2016 Jul;14(3):385-92. https://www.ncbi.nlm.nih.gov/pubmed/27143647
- Computer vision syndrome and associated factors among medical and engineering students in chennai. (2014). Logaraj M. Ann Med Health Sci Res. 2014 Mar;4(2):179-85. https://www.ncbi.nlm.nih.gov/pubmed/24761234
- [Meibomian gland disfunction in computer vision syndrome]. (2010) Pimenidi MK. Vests Oftalmol. 2010 Nov-Dec;126(6):49-52.
- Computer Vision Syndrome: A Review. (2005) Bleh C et al. Survey of Ophthalmology. May June 2005. Volume 50, Issue 3, Pages 253–262. https://www.surveyophthalmol.com/article/s0039-6257(05)00009-3/abstract https://www.ncbi.nlm.nih.gov/pubmed/29450383
- Mobile phone related-hazards and subjective hearing and vision symptoms in the Saudi population. (2005) Meo SA and Al-Dress AM. Int J Occup Med Environ Health. 2005;18(1):537. https://www.ncbi.nlm.nih.gov/pubmed/16052891
Dry Eye Syndrome
- Effects of long-term computer use on eye dryness. (2018) Akkaya S et al. North Clin Istan. 2018; 5(4): 319–322. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371992/
- Lacrimal Hypofunction as a New Mechanism of Dry Eye in Visual Display Terminal Users. (2010) Nakamura S et al. PLoS One. June 15, 2010; 5(6): e11119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886053/
Melatonin
- Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones’ Screens Improves Human Sleep Quality. (2018) Mortazavi SAR. J Biomed Phys Eng. 2018 Dec 1;8(4):375-380. https://www.ncbi.nlm.nih.gov/pubmed/30568927
- Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin. (2018) Zerbini G Eur J Neurosci. 2018 Dec 2. https://www.ncbi.nlm.nih.gov/pubmed/30506899
Myopia and Screen Time
- Associations Between Screen Exposure in Early Life and Myopia Amongst Chinese Preschoolers(2020) Yang GY et al. Int J Environ Res Public Health. 2020 Feb 7;17(3):1056. https://pubmed.ncbi.nlm.nih.gov/32046062/
- The Association Between Digital Screen Time and Myopia: A Systematic Review. (2020) Lanka and Saw. Ophthalmic Physiol Opt. 2020 Mar;40(2):216-229. https://pubmed.ncbi.nlm.nih.gov/31943280/
Skin Effects of Digital Screen Use
- Evaluation of Wi-Fi Radiation Effects on Antibiotic Susceptibility, Metabolic Activity and Biofilm Formation by Escherichia Coli0157H7,Staphylococcus Aureus and Staphylococcus Epidermis. (2019) Said-Salman IH et al. J Biomed Phys Eng. 2019,Oct; 9(5): 579–586. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820025/
- Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles? (2018) Arjmandi N et al. J Biomed Phys Eng. 2018 Dec 1;8(4):447-452. https://www.ncbi.nlm.nih.gov/pubmed/30568934
- Electronic Device Generated Light Increases Reactive Oxygen Species in Human Fibroblasts. (2018) Austin E et al. Lasers Sure Med. 2018 Feb 5. https://pubmed.ncbi.nlm.nih.gov/29399830/
- Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of Human Skin Fibroblast Migration. (2015) Mamalis A et al.PLoS One. 2015 Oct 21;10(10):e0140628. https://pubmed.ncbi.nlm.nih.gov/26488596/
Vision and Non-ionizing Radiofrequency Radiation (RFR) Exposure
- Fatal collision? Are wireless headsets a risk in treating patients? (2018) Sage and Hardell. Electromagnetic Biology and Medicine. Vol 37, 2018. https://www.tandfonline.com/doi/abs/10.1080/15368378.2017.1422261?src=recsys&journalCode=iebm20
- The effects of microwave radiation on rabbit’s retina. (2018) Journal of Current Ophthalmology. Vol 30. March 2018, Pages 74-79. https://www.sciencedirect.com/science/article/pii/S2452232517300562
- Rapidly Progressing Cataract after Microwave Exposure. (2015) Shucri Shawaf. MOJS. 2015, 2(1):00007. http://medcraveonline.com/MOJS/MOJS-02-00007.php
- Safe for Generations to Come. (2015) Wu T, Rappaport TS, and Collins CM . IEEE Microw Mag. 16(2): 65–84. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629874/
- Dosimetry Using a Localized Exposure System in the Millimeter-Wave Band for in vivo Studies on Ocular Effects.(2014) Sasaki et al., Transactions on Microwave Theory and Techniques. (2014) Sasaki K et al., . 19 May 2014, 62(7): 1554-1564. http://ieeexplore.ieee.org/document/6818422/
- Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats. (2014) Tok L.Indian J Ophthalmol. 2014 Jan;62(1):12-5. https://www.ncbi.nlm.nih.gov/pubmed/24492496
- [Increased occurrence of nuclear cataract in the calf after erection of a mobile phone base station]. (2012) Hässig M1, Jud F, Spiess B. Schweiz Arch Tierheilkd. 2012 Feb;154(2):82-6. https://www.ncbi.nlm.nih.gov/pubmed/22287140
- Bilateral vision loss associated with radio frequency exposure. (2012) Liu D et al. Clin Ophthalmology. 2012; 6: 2069–2073. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526913/
- [The injury effects of microwave exposure on visual performance and retinal ganglion cells (RGCs) in rats]. (2012) Wei AM et al. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseasesVolume 30, Issue 3, March 2012, Pages 172-177. https://www.scopus.com/record/display.uri?eid=2-s2.0-84877126930&origin=inward&txGid=64f4fe61e413791964ce671aa23a4928
- Non-thermal cellular effects of low power microwave radiation on the lens and lens epithelial cells. (2010) Yu Y and Yao K. J Int Med Res 38(3): 729-736. https://www.ncbi.nlm.nih.gov/pubmed/20819410
- [Effects of mobile phones and radar radiofrequencies on the eye]. (2009) Pathol Biol (Paris). 2009 Sep;57(6):503-8. https://medcraveonline.com/MOJS/MOJS-02-00007.pdf
- Prevalence of nuclear cataract in Swiss veal calves and its possible association with mobile telephone antenna base stations. (2009) Hässig M1, Jud F, Naegeli H, Kupper J, Spiess BM. Schweiz Arch Tierheilkd. 2009 Oct;151(10):471-8. https://www.ncbi.nlm.nih.gov/pubmed/19780007
- Non-Thermal Electromagnetic Radiation Damage to Lens Epithelium. (2008) Bormusov et al., Open Ophthalmol J. 2008; 2: 102–106. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694600/
- Non-thermal effects in the microwave induced unfolding of proteins observed by chaperone binding. (2008) George DF et al. Bioelectromagnetics, 29 (4) (2008), pp. 324-330. https://www.ncbi.nlm.nih.gov/pubmed/18240290
- The New Epidemiology of Cataract. (2006) Abraham et al., 2006 et al. Ophthalmology Clinic of North America. 19:415-425. https://www.researchgate.net/publication/6728154_The_New_Epidemiology_of_Cataract#pf9
- Localized effects of microwave radiation on the intact eye lens in culture conditions.(2005) Dovrat A et al. BioelectromagneticsVolume 26, Issue 5, July 2005, Pages 398-405. https://www.scopus.com/record/display.uri?eid=2-s2.0-22044451367&origin=inward&txGid=86949bc412d24db702cfcbb8c1258923
- Mobile phone related-hazards and subjective hearing and vision symptoms in the Saudi population. Meo SA et al. Int J Occup Med Environ Health. 2005;18(1):53-7. https://pubmed.ncbi.nlm.nih.gov/16052891/
- Low power microwave radiation inhibits the proliferation of rabbit lens epithelial cells by upregulating P27Kip1 expression. (2004) Yao K et al. Mol Vis. 2004 Feb 25;10:138-43. https://www.ncbi.nlm.nih.gov/pubmed/14990889
- Ocular effects of radiofrequency energy. (2003) Elder JA. Motorola Florida Research Laboratories. 2003;Suppl 6:S148-61. Elder JA1. https://www.ncbi.nlm.nih.gov/pubmed/14628311
- [Effect of low-intensity microwave radiation on proliferation of cultured epithelial cells of rabbit lens]. (2003) Wang KJ et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Oct;21(5):346-9. https://www.ncbi.nlm.nih.gov/pubmed/14761396
- The effects of low level microwaves on the fluidity of photoreceptor cell membrane. (2002) Roxana Pologea Moraru et al. Bioelectrochemistry. Vol 56. 15 May 2002, Pages 223-225 https://www.sciencedirect.com/science/article/abs/pii/S1567539402000373
- Low power density microwave radiation induced early changes in rabbit lens epithelial cells. (2001) Ye et al., 2001 Chin Med J (Engl). 114(12):1290- 4. https://www.ncbi.nlm.nih.gov/pubmed/11793856
- Effects of Microwave and Millimeter Wave Radiation on the Eye. In Radiofrequency Radiation Dosimetry and its Relationship to the Biological Effects of Electromagnetic Fields. 2000. D’Andrea JA and Chalfin S. https://link.springer.com/chapter/10.1007/978-94-011-4191-8_43
- Development and repair of cataract induced by ultraviolet radiation. (2000) Michael R. Ophthalmic Res. 2000;32 Suppl 1:ii-iii; 1-44. https://www.ncbi.nlm.nih.gov/pubmed/10817682
- Absence of ocular effects after either single or repeated exposure to 10 mW/cm(2) from a 60 GHz CW source. (1999) Kues HA. Bioelectromagnetics. 1999 Dec;20(8):463-73. https://www.ncbi.nlm.nih.gov/pubmed/10559768
- Lipid peroxide damage in retinal ganglion cells induced by microwave. (1999) Yang R et al. Wei sheng yan jiu = Journal of hygiene researchVolume 28, Issue 4, Jul 1999, Pages 200-202. https://www.scopus.com/record/display.uri?eid=2-s2.0-0033167552&origin=inward&txGid=e721c89a7916df47ab437d35d59aff75
- Oxidative stress-induced cataract: mechanism of action. (1995) Spector A. FASEB Journal. 9:1173-82. http://www.fasebj.org/content/9/12/1173.short
- Experimental studies on the influence of millimeter radiation on light transmission through the lens. (1994) Prost M et al., Klin Oczna. 1994 Aug-Sep;96(8- 9):257-9. https://www.ncbi.nlm.nih.gov/pubmed/7897988
- Microwave-Induced Changes to the Primate Eye. (1992) Kues HA and Monahan JC. Johns Hopkins APL Technical Digest, Volume 13, Number 1. http://www.jhuapl.edu/techdigest/views/pdfs/V13_N1_1992/V13_N1_1992_Kues.pdf
- Effects of microwave radiation on the eye: The occupational health perspective. (1989) Cutz A. Lens and eye Toxicity Research. 6(1-2):379-386. http://europepmc.org/abstract/med/2488031
- Cataracts induced by microwave and ionizing radiation. (1988) Lipman et al., Ophthalmol. 33(3): 200-10. https://www.ncbi.nlm.nih.gov/pubmed/3068822
- In vitro studies of microwave-induced cataract. II. Comparison of damage observed for continuous wave and pulsed microwaves.(1987) Creighton MO et al. Exp Eye Res. 1987 Sep;45(3):357-73. https://www.ncbi.nlm.nih.gov/pubmed/3666062https://www.ncbi.nlm.nih.gov/pubmed/3666062
- Potential ocular damage from microwave exposure during electrosurgery: dosimetric survey. (1987) Paz JD et al. J Occup Med. 1987 Jul;29(7):580-3. https://www.ncbi.nlm.nih.gov/pubmed/3612334
- Data analysis reveals significant microwave-induced eye damage in humans. (1985) Frey AH. J Microw Power Electromagn Energy. 1985;20(1):53-5. https://www.ncbi.nlm.nih.gov/pubmed/3847507
- Rabbit eye exposure to broad-spectrum fluorescent light. (1983) Pitts DG et al., Acta Ophthalmol Suppl. 1983;159:1-54. https://www.ncbi.nlm.nih.gov/pubmed/6318510
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- Crosby PA. MICROWAVES AND OCULAR PATHOLOGY A REVIEW. Australian Journal of Ophthalmology. 1979. P 163-166. https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1442-9071.1979.tb01416.x
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- Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. (2013). Behar-Cohen F et al. Cain. Ophthalmology 2014; 8: 87–104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872277/
- Ultraviolet phototoxicity to the retina. (2011). Glickman RD. Eye Contact Lens. 2011 Jul;37(4):196-205. https://www.ncbi.nlm.nih.gov/pubmed/21646980
- Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair. (2010) Rastogi RP et al. J Nucleic Acids. 2010; 2010: 592980. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010660/
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